Quick answer
Wellbutrin (bupropion) is an antidepressant used for major depression, especially when symptoms include low energy and poor concentration. It works by increasing dopamine and norepinephrine levels in the brain, unlike SSRIs. A clinician can determine if it's right for you after a full video evaluation and provide ongoing care.
How Wellbutrin Works for Depression
Wellbutrin, the brand name for bupropion, is an FDA-approved antidepressant for major depressive disorder (MDD) and seasonal affective disorder (SAD). It works differently than the most common antidepressants, which are known as SSRIs.
Wellbutrin is an NDRI, or norepinephrine-dopamine reuptake inhibitor. It works by increasing two key chemicals in your brain: norepinephrine and dopamine. These chemicals help regulate mood, motivation, and energy. This unique function makes Wellbutrin a useful option if SSRIs haven't worked for you.
When Clinicians Consider Wellbutrin
Your provider may consider Wellbutrin if your depression includes symptoms like deep fatigue, low motivation, or mental sluggishness. It can also help with anhedonia, the loss of pleasure in things you once enjoyed. The medication boosts dopamine, a brain chemical linked to reward and motivation.
Wellbutrin isn't right for everyone. It is generally not prescribed if you have a seizure disorder, as it can lower the seizure threshold. It is also typically avoided if you have a history of bulimia or anorexia. A full evaluation with a clinician is the only way to know if it's a safe option for you.
Wellbutrin vs. SSRIs: Side Effects
Wellbutrin's side effects are often different from those of SSRIs. Many people find it has a much lower risk of causing sexual side effects, like reduced libido. It's also less likely to cause weight gain than some other antidepressants.
However, Wellbutrin has its own set of possible side effects. These can include insomnia, dry mouth, headache, or increased anxiety. Your clinician will review your health history to help you weigh the benefits and risks.
Your First Appointment
Finding the right treatment starts with a complete psychiatric evaluation. Your first appointment is a 30-40 minute video call with a licensed clinician. They will take the time to understand your symptoms, health history, and treatment goals.
This first meeting is about making an accurate diagnosis and a personalized plan. To ensure continuity of care, you will see the same clinician for every follow-up visit. This consistency helps them monitor your progress and make thoughtful adjustments to your treatment.
Insurance and Scheduling
We offer telehealth psychiatry in 46 U.S. states and the District of Columbia. We accept most major insurance plans, including Aetna, Blue Cross Blue Shield, Cigna, and United Healthcare. Our team will verify your benefits before your first visit.
To allow time for this process, we ask for at least 72 hours' notice when you schedule an appointment using insurance. If you prefer to pay yourself, the rate is $150 per visit.
Important to Know
This content is for informational purposes only and does not constitute medical advice. All medical decisions require a comprehensive evaluation by a licensed clinician. Any prescription is at the sole discretion of the provider based on their clinical judgment. Telehealth services may vary by state law.
Our services are for non-emergency care. If you are in crisis or have a medical emergency, please call or text 988, or go to the nearest emergency room.
Frequently Asked Questions
How long does Wellbutrin take to work for depression?
Like many antidepressants, bupropion can take four to six weeks to reach its full effect. Some people, however, may notice improvements in energy or focus sooner. Consistent use as prescribed is key to seeing results.
What is the difference between Wellbutrin XL and SR?
The letters refer to the drug's release formula. SR stands for 'Sustained-Release' and is usually taken twice a day. XL stands for 'Extended-Release' and is taken once daily. Your clinician will decide which version best fits your needs.
Can Wellbutrin be prescribed with another antidepressant?
Yes, sometimes a clinician may add Wellbutrin to an SSRI or SNRI. This can help target a wider range of symptoms or reduce certain side effects. This decision requires careful clinical judgment and is always managed by a licensed provider.
How are telehealth appointments conducted?
All our psychiatric appointments are held on a secure, private video platform. This allows you to meet with your provider from home or another convenient location, ensuring your privacy and making care easier to access.
Can Wellbutrin make anxiety worse?
For some people, bupropion can increase feelings of anxiety or agitation, especially when first starting the medication. Your clinician will monitor this closely and may adjust your dose. It's important to share any new or worsening symptoms with your provider.
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